Abhay Deshpande, founder & chief investment officer of Centerstone Investors, joins Yahoo Finance to discuss investing in European stocks and the re-opening trade.
Abhay Deshpande, founder & chief investment officer of Centerstone Investors, joins Yahoo Finance to discuss investing in European stocks and the re-opening trade.
The CDC and FDA are recommending a pause in the use of the one-shot, Johnson & Johnson vaccine. Latest COVID updates.
Jurors were expected to hear from defense witnesses in the trial of former Minneapolis police officer Derek Chauvin, charged in George Floyd's death.
Inside the Nashville basement studio of audio engineer Gena Johnson, she has mementos from many of the artists she's helped to record and who have also shaped her own career. A turn of the century upright piano that Ben Folds helped her find sits next to the entrance. Polaroids of her and singer Ashley Monroe are scattered on her mixing board, and a sign in the lounge offers a cocktail called Handsome Johnny, a signature vodka drink that the late John Prine named after himself.
President Bashar Assad sacked the governor of war-ravaged Syria’s Central Bank on Tuesday amid a crash in the currency in recent months. State media did not give a reason for the removal of Hazem Qarfoul from the post he held since late 2018. The Syrian pound set a record in March trading on the black market at 4,600 pounds to one U.S. dollar before improving to 3,100.
Officials recommended the pause 'out of an abundance of caution,' saying blood clots still seem to be 'extremely rare,' according to a statement.
Side-effects have been reported for all three vaccines approved for emergency use in the US but most are mild and short-livedAs more people become eligible to receive a coronavirus vaccine many are asking what side-effects they should expect, and if there are differences between the side-effects of the vaccines. The short answer to both questions is yes – the details are below – though any discomfort pales in comparison with contracting Covid-19. We used clinical trial data gathered by the US Food and Drug Administration (FDA) to explore the kinds of side-effects most commonly associated with the three vaccines currently authorized for emergency use in the US. Those vaccines were developed by Pfizer and BioNTech, Moderna and the National Institute of Allergy and Infectious Disease (Niaid) and most recently by Johnson & Johnson. What are the common side-effects? For all the vaccines, the most common side-effects include: Soreness where the vaccine is injected. Fatigue. Headache and muscle soreness. Less common side-effects can also include nausea, chills and fever. The vast majority of symptoms cause discomfort, but not a total disruption of your daily habits. Are Covid-19 vaccines safe? Yes. Their safety is tested in large trials of tens of thousands of people, then the FDA and the Centers for Disease Control and Prevention (CDC) continue to monitor vaccine safety data, including side-effects, after the vaccines are authorized. These are sometimes referred to as phase IV trials. That monitoring goes hand-in-hand with reporting through several vaccine safety registries. These ongoing studies can help identify the rarest of side-effects, and pinpoint people who may have special sensitivities to the vaccine, such as a potential for an allergic reaction. One of the key numbers included in the graphs below is the rate of people who experienced side-effects after receiving a “placebo”, or an injection of saline instead of the vaccine. People involved in the trials did not know whether or not they received the vaccine. This helps researchers understand the background rate of these side-effects in the population. Moderna vaccine side-effects Formally called mRNA-1273, this vaccine was developed by Moderna in partnership with the Niaid, but most people simply know it as the Moderna vaccine, which is a two-dose regimen spaced 28 days apart. A clinical trial involving more than 30,000 participants across 99 sites in the US found the vaccine was safe and effective, and protected people against Covid 94.1% of the time. Among those trial participants, 15,168 people received the vaccine and the rest received a placebo. Moderna dose 1 side-effects We used results from the vaccine’s trials to describe how likely it is for people aged 18 to 64 to experience a given side-effect within one week of a dose of the vaccine. On average, these symptoms cleared up within three days, and often less. default Moderna dose 2 side-effects A key feature of the two-dose regimen is that people are more likely to experience side-effects after the second dose. default Pfizer vaccine side-effects A vaccine developed by Pfizer with the pharmaceutical name BNT162B2 uses mRNA technology, much like Moderna’s vaccine. Their trial used 152 sites around the world. While the majority (130) were in the US, trial sites were also located in Brazil, Argentina and South Africa. More than 43,000 people were involved in the trial. The vaccine was found to be 95% effective at preventing Covid-19. Pfizer’s vaccine uses a two-dose regiment spaced 21 days apart. Pfizer dose one side-effects Unlike Moderna, Pfizer studied side-effects in two separate age groups: people between aged 16 and 55, and people older than 55. Because people older than 55 are slightly less likely to experience side-effects, the younger group is presented here. default Pfizer dose two side-effects Like the Moderna vaccine, some side-effects were more common after the second dose. default Johnson & Johnson side-effects The most recent vaccine authorized in the US is from the Johnson & Johnson subsidiary Janssen. Johnson & Johnson’s trial included more than 40,000 people across 19 geographic regions. Importantly, this included South Africa, where the vaccine was found to be slightly less effective against the B1351 variant. The FDA found this vaccine is more than 66% effective at preventing moderate to severe Covid-19. While this efficacy rate is lower than the two previously discussed vaccines, it still gives near perfect protection against hospitalization and death, and provides advantages in fighting the pandemic. On 13 April, the FDA and CDC recommended that states pause the administration of the Johnson & Johnson vaccine after reports that six women developed rare and severe blood clots. While serious, these side effects are exceedingly rare. More than 6.8m doses have been administered nationally. Johnson & Johnson side-effects The Johnson & Johnson vaccine requires only one dose, has a generally lower rate of side-effects. default What causes the side-effects? Side-effects are a sign the vaccine is prompting your body to mount an immune response. They may be uncomfortable, but can also be a sign the vaccine is working as intended. Side-effects are caused by the release of chemicals in the body which signal to the immune system it is time to mount a response. These naturally occurring chemicals are called cytokines and chemokines. Though there is not a one-to-one correlation between side-effects and an immune response, side-effects are an expected part of the process. “What we look for as vaccinologists is the Goldilocks response,” said Dr Greg Poland, editor-in-chief of the medical journal Vaccine and head of the Vaccine Research Group at the Mayo Clinic. Poland also consults for major vaccine manufacturers. “We don’t want too little” immune response, “we don’t want too much, we want just enough,” said Poland. The balance Poland is describing is sometimes referred to as between “immunogenicity” and “reactogenicity”, or the propensity to prompt an immune response versus the tolerability of side-effects. Why should I trust this data? In vaccine science, these often mild side-effects are described as “adverse events”. In Covid-19 vaccine studies, researchers collected information on everything from hip fractures to heart attacks to monitor the safety of these vaccines. “We have a very, very robust system in the US,” to track adverse vaccine events, said Poland. “It’s how we were able to pinpoint a risk of anaphylaxis in specific kinds of people occurring at the rate of 2.4-4.5 per million, something you could never have done in this kind of timely manner in the past.” Importantly, the vast majority these side-effects are not related to vaccines, but are nevertheless documented to ensure there is not a pattern, and to verify the safety of one of the only medical interventions given to healthy people. The FDA then produces its own analysis of vaccine trials, and the data is presented to an independent panel of experts, who review it and make a recommendation on whether to authorize the vaccines based on the results. The FDA analyses presented to the committee are public, and can be viewed here, as can meetings of this expert panel.
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FDA and CDC release statement recommending pauseSix reported US cases of ‘rare and severe problem’ Johnson & Johnson developed a single-shot Covid-19 vaccine. Photograph: Tom Williams/CQ-Roll Call, Inc/Getty Images US health agencies have recommended states pause the administration of the Johnson & Johnson coronavirus vaccine, after reports of rare and severe blood clots emerged in six women. More than 6.8m doses have been administered nationally. The concerns mirror those of drugs agencies in Europe and Australia over the AstraZeneca vaccine, which has not authorized in the US. There have been no significant safety concerns raised about the two other vaccines that make up the majority of US supply, from Pfizer-BioNTech and Moderna. The FDA and CDC said in a joint statement: “People who have received the J&J vaccine who develop severe headache, abdominal pain, leg pain, or shortness of breath within three weeks after vaccination should contact their healthcare provider.” All six women were between the ages of 18 and 48. One woman died, and a woman in Nebraska is hospitalized in critical care, according to the New York Times. Johnson & Johnson’s vaccine is also under scrutiny by the European Medicines Agency, which is investigating four cases of clotting. Health agencies said the blood clotting concern is “extremely rare”. Authorities are still investigating whether the clotting is indeed caused by the vaccine. Technically, the disorder is a thrombosis, or blood clot, with thrombocytopenia, a low count of platelets, the component of blood responsible for clotting. The same symptoms have been observed in a very small number of AstraZeneca recipients. As of 4 April, there have been 222 cases of blood clots among the more than 34 million globally who have received the AstraZeneca vaccine. The European Medicines Agency has examined 86 cases of blood clots, 18 of which have been fatal. J&J said in a statement: “The safety and wellbeing of the people who use our products is our No 1 priority. At present, no clear causal relationship has been established between these rare events and the Janssen Covid-19 vaccine. We continue to work closely with experts and regulators to assess the data and support the open communication of this information to healthcare professionals and the public.” Janssen is the division of Johnson & Johnson that developed the vaccine. J&J and AstraZeneca use a vaccine technology called an adenovirus platform to prompt immunity. The technology uses a second, weakened cold virus to deliver the genetic payload of the coronavirus to the immune system, and spur the body to make antibodies. However, a mechanism that may cause the potential connection between clotting and the adenovirus platform is not clear. Moderna and Pfizer use a different vaccine platform called messenger RNA, to provoke the body to build antibodies. Independent experts have said the “pause” in administration shows federal monitoring systems for potential adverse side effects of the vaccine are working. Ashish Jha, the dean of the Brown University school of public health, said on Twitter: “My sense is confidence comes from people believing that we have a vigorous system that takes adverse events seriously.” He said, “while unfortunate,” the pause is the “right step”. Scott Gottlieb, a former FDA commissioner, said on CNBC’s Squawk Box: “For most consumers, I wouldn’t be concerned about this. Really this is an alert to doctors. That’s how FDA framed it. It’s advice to doctors to be monitoring more closely.” The pause in administration of the Johnson & Johnson vaccine may also cause a hit to the American immunization campaign, which was set to administer hundreds of thousands of easy-to-administer doses provided by the company. The White House denied the pause would have a significant impact. Jeff Zients, the White House Covid response chief, said: “This announcement will not have a significant impact on our vaccination plan. [The] vaccine makes up less than 5% of the recorded shots in arms in the US to date.” Johnson & Johnson’s vaccine requires only one dose, and can be stored in a common refrigerator. Pfizer and Moderna’s vaccine require ultra-cold storage and a two-dose regiment. The pause represents a blow to Johnson & Johnson, which recently was forced to throw away between 13m and 15m doses of vaccine after a federal contractor botched doses. The J&J pause at a perilous time in the pandemic. In spite of the strides made in immunizing all adult Americans, with 74 million people and 22% of the public fully immunized, Covid-19 cases are rising in several states, such as Minnesota, and remain high in others, such as Michigan. With a weary public and the return of warm weather in much of the country, politicians have had little appetite to renew restrictions on social life and many instead say the vaccination campaign can curb cases. The new concerns are also likely to inflame partisan tensions and the conspiracy theorists. Republicans, especially men, remain the most hesitant to receive a coronavirus vaccine after national politicians and Donald Trump downplayed the seriousness of the virus. Vaccine hesitancy could play an increasingly significant role in whether the US is able to curb the pandemic, or if the viral spread is allowed to continue and circulate regionally. Although the exact level of immunity needed to squash viral spread is not known, experts believe between 70-90% of the public will need to be vaccinated. Because children make up about a quarter of the US population, that level of immunity would require nearly every US adult to be vaccinated to stop spread. Federal regulators said they will convene an emergency meeting of vaccine regulators to discuss the matter. A press conference was expected on Tuesday morning.
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When the U.S. government enacted a ban on evictions, it did so through an unlikely agency: the Centers for Disease Control and Prevention. The CDC has said the policy, first enacted in September and recently extended through the end of June, helps stop the spread of the coronavirus by limiting the number of people who lose their housing and have to live in shared housing, homeless shelters or on the streets. Here’s a look at the moratorium, its rationale and what the research says about evictions and health.
Stocks traded mixed on Tuesday after U.S. federal health officials called for a pause in the rollout of Johnson & Johnson's (JNJ) COVID-19 vaccine amid concerns over rare blood clots in some individuals who received the inoculation.
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Egyptian authorities impounded a massive cargo vessel that blocked the Suez Canal last month amid a financial dispute with its owner, the canal chief and a judicial official said Tuesday. Lt. Gen. Osama Rabie said the hulking Ever Given would not be allowed to leave the country until a compensation amount is settled on with the vessel's Japanese owner, Shoei Kisen Kaisha Ltd.