Jacksonville Jaguars vs. Indianapolis Colts picks, predictions: Who wins NFL Week 6 game?

Jeremy Cluff, Arizona Republic

October 12, 2022 at 1:47 PM·3 min read

The Jacksonville Jaguars and Indianapolis Colts play on Sunday in a game on the NFL Week 6 schedule.

Which team will get the victory?

Check out these NFL Week 6 picks and predictions for the game, which can be seen at 10 a.m. MST on CBS.

The Colts are a 1.5-point favorite in the game.

VOTE: What's your prediction for the #Jaguars vs. #Colts #NFL Week 6 game? (Picks: https://t.co/UOAopEkqpt | Odds: https://t.co/8mgGXlwEIP) #DUUUVAL #ForTheShoe @azcentral
— azcentral sports (@azcsports) October 12, 2022

The Arizona Republic: Colts 21, Jaguars 20

Jeremy Cluff writes: "You can bet the Colts have their 24-0 Week 2 loss to the Jaguars on their minds."

Bookies.com: Bet the Colts to cover vs. Jaguars

Bill Speros writes: "The Colts and Jaguars combined to score 18 points in Week 5 off six field goals. The first touchdown could win this one. The new Matt Ryan (Trevor Lawrence) meets the old Trevor Lawrence (Matt Ryan). Given that the AFC South may come down to the 47th tie-breaker when the Jaguars, Titans and Colts all finish 8-9, this one carries some long-term weight. The outcome of this game could well hinge on the presence (or lack thereof) of Colts running back Jonathan Taylor. He's expected to be back."

NFL Week 6 odds:

Will Stephon Gilmore and the Indianapolis Colts beat the Jacksonville Jaguars in their NFL Week 6 game on Sunday?

ESPN: Jaguars have a 38.4% chance to win the Week 6 game

The site's Football Power Index gives the Colts a 61.2% chance to get the victory.

Draft Kings: Take the Jaguars with the points vs. Colts

It writes: "Lawrence’s performance in Week 5 was underwhelming to put it lightly, but they have the relative health advantage heading into this AFC South matchup. It remains to be seen whether Taylor or Hines will be available for the Colts, which is a huge blow to the backfield. If either or both can’t go, Jacksonville ideally should have the upper hand in this contest and should cover as a result."

How to watch: NFL Week 6 schedule, television information

Sports Betting Dime: Jaguars 21.5, Colts 5.5

The site's formula is predicting a big win for the Jaguars in the NFL Week 6 game against the Colts on Sunday.

Fan Duel: Go with the Jaguars on the moneyline vs. Colts

Larry Rupp writes: "Both of these teams are in contention for the AFC South title and have been up and down in 2022. Give me the team with the better offensive line in the Jaguars. The Colts are letting quarterback Matt Ryan get sacked far too frequently, which is resulting in stalled drives and costly turnovers. Head coach Doug Pederson will get the rebuilding Jags back on track here."

NFL power rankings: Minnesota Vikings, Dallas Cowboys, New York Giants sizzle

Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on Twitter @Jeremy_Cluff.

Support local journalism: Subscribe to azcentral.com today.

This article originally appeared on Arizona Republic: Jacksonville Jaguars vs. Indianapolis Colts picks NFL Week 6 game

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