Advertisement

Alnylam Posts Mid-Stage Study Data From Regeneron-Partnered Kidney Disease Drug

  • Alnylam Pharmaceuticals Inc (NASDAQ: ALNYannounced results from a Phase 2 study of cemdisiran for immunoglobulin A nephropathy (IgAN).

  • Cemdisiran is an investigational RNAi therapeutic targeting the C5 component of the complement pathway and is under development in collaboration with Regeneron Pharmaceuticals Inc (NASDAQ: REGN).

  • New results demonstrated a 36% reduction in 24-hour urine total protein and a higher proportion, 32% versus 13%, of patients treated with cemdisiran as compared to those on placebo, respectively, achieving greater than or equal to 50% reduction in 24-hour UPCR.

  • Related: Why Alnylam Pharma Shares Are Trading Higher During Premarket Session.

  • Spot urine data were consistent with 24-hour urine data, with the initial onset of treatment effect emerging as early as Week 8 and remaining stable over time. Patients on cemdisiran achieved a 46% placebo-adjusted reduction from baseline in spot UPCR at 32 weeks.

  • The results showed that cemdisiran was generally well tolerated with no adverse events. One death occurred in the cemdisiran arm due to cardiorespiratory collapse; this was not considered related to the study drug.

  • Price Action: ALNY shares are down 0.68% at $209.51 on the last check Monday.

See more from Benzinga

ADVERTISEMENT

Don't miss real-time alerts on your stocks - join Benzinga Pro for free! Try the tool that will help you invest smarter, faster, and better.

© 2022 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.